Relationships between Staphylococcus aureus Genetic Background, Virulence Factors, agr Groups (Alleles), and Human Disease
نویسندگان
چکیده
منابع مشابه
Relationships between Staphylococcus aureus genetic background, virulence factors, agr groups (alleles), and human disease.
The expression of most Staphylococcus aureus virulence factors is controlled by the agr locus, which encodes a two-component signaling pathway whose activating ligand is an agr-encoded autoinducing peptide (AIP). A polymorphism in the amino acid sequence of the AIP and of its corresponding receptor divides S. aureus strains into four major groups. Within a given group, each strain produces a pe...
متن کاملStaphylococcus aureus virulence factors and disease
The genus Staphylococcus is composed of Gram-positive bacteria with diameters of 0.5-1.5 μm, characterized by individual cocci that divide in more than one plane to form grape-like clusters [1]. These bacteria are non-motile, nonspore forming facultative anaerobes, featuring a complex nutritional requirement for growth [2-4], a low G+C content of DNA (in the range of 30-40 mol%) [5], a toleranc...
متن کاملEpistatic Relationships between sarA and agr in Staphylococcus aureus Biofilm Formation
BACKGROUND The accessory gene regulator (agr) and staphylococcal accessory regulator (sarA) play opposing roles in Staphylococcus aureus biofilm formation. There is mounting evidence to suggest that these opposing roles are therapeutically relevant in that mutation of agr results in increased biofilm formation and decreased antibiotic susceptibility while mutation of sarA has the opposite effec...
متن کاملAssociation of agr Gene Expression with Staphylococcus Aureus Virulence Genes in BHI Broth
Abstract Background and Objective: Agr is the most important regulatory system for the expression of Staphylococcus aureus virulence factors in different conditions. Agr acts as a quorum sensing system in this bacterium which is activated by increased cell concentration during the transition from logarithmic growth phase to stationary phase. Its role is to up...
متن کاملAgr interference between clinical Staphylococcus aureus strains in an insect model of virulence.
Repression of virulence by Staphylococcus aureus strains from different Agr groups has been demonstrated in vitro and is proposed as a means of competitive interference. Here, using the insect Manduca sexta, we show for the first time that this interference also occurs in vivo within a mixed population.
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2002
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.70.2.631-641.2002